Honokiol

Chronic Hepatitis

Honokiol
Honokiol

Composition:
Each capsule contains:
Magnolia officinalis bark extract containing Honokiol ……………. 100 mg

Phytochemistry:
The extract of Magnolia officinalis bark contains honokiol which belongs to the class of neoligninbiphenols. As a polyphenol, it is relatively small and can interact with cell membrane proteins through intermolecular interactions. It is hydrophobic and readily dissolved in lipids.

Pharmacological actions:
Honokiol can readily cross the blood brain barrier and therefore is a potentially potent therapy with high bioavailability. It has been shown to have antidepressant, anxiolytic, antioxidant, anti-HCV and anti-tumour effects.

Effect on CNS: Honokiol has been shown to promote neurite outgrowth and have neurotrophic effects in rat cortical neurons.

Effect on tumour: Honokiol has shown pro-apoptotic effects in melanoma, sarcoma, leukaemia, prostate, bladder, lung, and oral squamous cell carcinoma and colon cancer cell lines.

Effect on HCV: Honokiol inhibits the entry and replication steps of HCV life cycle in vitro, according to research done in National Yang-Ming University, Taipei, Taiwan.

Benefits:
◆ To reduce anxiety and enhance sleep
◆ Adjuvant treatment for Hepatitis C virus infection
◆ Supportive treatment for cancers

Dosage:
Adult – one to two capsules two times daily after meal

Side effects:
Heartburn, shaking hands, perilabial numbness in some individuals.

Contraindication:
Renal insufficiency, pregnancy and lactation

Drug interaction:
Honokiol may interact with paracetamol, benzodiazepine (additive effect), antiplatelet medication (additive effect). It may also stimulate corticosterone secretion or increase steroid medication concentrations. It may cause sleepiness, drowsiness, vertigo and dizziness in patients taking muscle relaxants.

Quantity supplied:
60 capsules per bottle

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