Composition:
Each capsule contains:
Magnolia officinalis bark extract containing Honokiol . . . . . . . 100 mg

Phytochemistry:
The extract of Magnolia officinalis bark contains honokiol which belongs to the class of neoligninbiphenols. As a polyphenol, it is relatively small and can interact with cell membrane proteins through intermolecular interactions. It is hydrophobic and readily dissolved in lipids.

Pharmacological actions:
Honokiol can readily cross the blood brain barrier and therefore is a potentially potent therapy with high bioavailability. It has been shown to have antidepressant, anxiolytic, antioxidant, anti-HCV and anti-tumour effects.

Effect on CNS: Honokiol exerts neuroprotective properties through a variety of mechanisms. It has been shown to interact with neurotransmitter gamma-aminobutyric acid (GABA) receptors. The present study indicates a significant anti-stress benefit of honokiol from magnolia supplement in moderately stressed adults. Honokiol has been shown to promote neurite outgrowth and have neurotrophic effects in rat cortical neurons. It was found to significantly shorten sleep latency. It excites sleep-promoting neurons in the ventrolateral preoptic areas.

Effect on tumour: Honokiol has shown pro-apoptotic effects in melanoma, sarcoma, leukaemia, prostate, bladder, lung, and oral squamous cell carcinoma and colon cancer cell lines.

Benefits:
◆ To reduce anxiety and enhance sleep
◆ Supportive treatment for cancers

Dosage:
Adult – one to two capsules two times daily after meal

Side effects:
Heartburn, shaking hands, perilabial numbness in some individuals.

Contraindications:
Renal insufficiency, pregnancy and lactation

Drug interactions:
Honokiol may interact with paracetamol, benzodiazepine (additive effect), antiplatelet medication (additive effect). It may also stimulate corticosterone secretion or increase steroid medication concentrations. It may cause sleepiness, drowsiness, vertigo and dizziness in patients taking muscle relaxants.

Quantity supplied:
60 capsules per bottle