Probiotics for cholesterol lowering

Each capsules contains:
Lactobacillus acidophilus …………………….. 1.5 billion CFU*
Lactobacillus casei …………………….. 1.5 billion CFU*
Lactobacillus plantarum …………………….. 1.5 billion CFU*
Pediococcus pentosaceus …………………….. 1.5 billion CFU*
* Initial cell count
Our coating technology ensures 100 times higher survival rate than uncoated probiotics in the intestine.

Health benefits:
◆ Support fat burning
◆ Promote healthy weight loss
◆ Modulate energy metabolism
◆ Help to dissolve gallstone

Probiotics (gut microbiota) can modulate body weight and energy metabolism. The following mechanisms play a major role.

Short-chain fatty acid (SCFAs) production: Probiotics ferment non-digestible polysaccharides, thereby producing a large amount of SCFAs that represent an important energy source, nearly 10% of the daily energy supply. SCFAs interact with G-protein coupled receptors Gpr41 and Gpr43 that reduce gut motility, promote satiety and suppress energy intake. SCFAs-Gpr41 and -Gpr43 interactions stimulate leptin production and profoundly affect inflammatory responses that are responsible for the development of obesity-related metabolic disturbances such as insulin resistance, lipogenesis and increased triglyceride stores.

Binding and incorporation of cholesterol: The hypocholestrolemic effect of probiotics has also been attributed to their ability to bind cholesterol in the small intestines. Cholesterol was also removed by probiotics by incorporation into the cellular membranes during growth. It can also be converted in the intestines to coprostanol, which is directly excreted in feces. Consequently, dietary cholesterol would be less available for absorption in the intestine.

Regulation of bile acid metabolism: Probiotics deconjugate bile acids through the action of microbial enzymes. Bacterial bile salt hydrolases (BSH) are produced by various microbial species including Lactobacillus. Deconjugated bile acids are poorly absorbed and mainly excreted with the feces. This can reduce serum cholesterol levels because de novo bile acid synthesis from cholesterol is stimulated. Farnesoid X receptor (FXR) is a metabolic regulator involved in energy homeostasis, bile acid homeostasis and glucose metabolism. The gut microbiota influence on nuclear FXR activity appears to be critical for body weight increase and glucose and lipid homeostasis.

One to two capsules daily. The dosage can be adjusted according to requirement.

Side effect:
Soft stool may occur in some individuals.

Mixing with hot food and drink should be avoided.
Alcohol can destroy the probiotics.

Store under 25°C, away from moisture and direct sunlight. Keep refrigerated to maintain potency.

Quantity supplied:
30 vegetarian capsules per bottle

Copyright© 2022 FAME Pharmaceuticals Industry Co., Ltd. All rights reserved.