Luteolin

Chronic Hepatitis

Luteolin

Composition:
Each capsule contains
Luteolin from Thymus vulgaris extract ………………………………. 100 mg

Pharmacological actions:
Anti-HCV activity

According to research done by the Fudan University in China, luteolin displayed an anti-HCV activity (as HCV replication inhibitor) with EC50 value of 4.3 µM in cell-based antiviral assay. Luteolin exhibited a good inhibition of NS5B polymerase enzymatic function with an IC50 of 1.12 µM.

Anti-tumour activity
A group of scientists from the Kaohsiung Medical University of Taiwan tested luteolin against five human hepatoma cell lines, namely HepG2, SK-Hep-1, PLC/PRF/5, Hep3B, and HA22T/VGH, with XTT assay and flow cytometry. The results showed that luteolin inhibited HCC cells not only by cell cycle arrest at G0/G1 phase but also by apoptosis.

Glucose absorption lowering
Luteolin inhibits alpha-glucosidase and alpha-amylase suggesting that it can suppress postprandial hyperglycemia in patients with non-insulin dependent diabetes mellitus. The anti-diabetic property of luteolin was reported by Zarzuelo et al 1996 where a significant decrease in glycemia levels (>50%), a 2.5-fold increase in insulin blood levels and elevated pancreatic insulin were observed.

Healthy weight maintenance
Scientific studies showed that luteolin increased peroxisome proliferator-activated receptor gamma (PPARg) protein expression to attenuate hepatic lipotoxicity, which links to the improvement in circulating fatty acid (FA) levels by enhancing FA uptake genes and lipogenic genes and proteins in adipose tissue. It also upregulated the expression of genes controlling lipolysis and tricarboxylic acid (TCA) cycle prior to lipid droplet formation, thereby reducing adiposity. Increased consumption of dietary flavonoids eg. luteolin was associated with weight maintenance.

Benefits:
● Adjuvant treatment for Chronic Hepatitis C
● Supportive treatment for Tumour of the liver (Hepatoma)
● Glucose absorption lowering
● Healthy weight maintenance

Dosage:
Adult – one capsule two times daily

Combination Therapy:
It can be used together with MilkThistle (silymarin), GreenTea (EGCG), Appletec® (quercetin) and Blueberry (proanthocyanidin) for more synergistic action.

Quantity supplied:
60 capsules per bottle

FAME Pharmaceuticals Industry Co., Ltd.
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Office: +95 (1) 3685 083, 3682 199, 3685 609, Fax: +95 (1) 3680 122,
E-mail: sale@famepharma.com, drkml@famepharma.com

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