MilkThistle

80% Silymarin

MilkThistle

Composition:
Each tablet contains:
Milk thistle seed extract ………………………………. 200 mg
(Standardized to 80% silymarin )
Soy bean powder …………………………………………… 100 mg

Pharmacological Actions:
1. Hepatoprotective effects

Silymarin’s ability to protect liver destruction and enhance liver function is largely due to its inhibition of the factors that are responsible for hepatic damage, i.e.free radicals and leukotrienes, coupled with its ability to stimulate liver protein synthesis. Silymarin components prevent free radical damage by acting as antioxidants. Silymarin is many times more potent in antioxidant activity than vitamin E. Unlike most flavonoid antioxidants, silymarin does not remain in the plasma and mainly an affinity for liver.

2. Enhance hepatic glutathione activity
Glutathione is one of the most important antioxidant molecules for elimination of cytotoxicity in human. Silymarin’s affinity for liver tissue has been shown to substitute for depleted glutathione in hepatocytes. Even in normal it increases the basal GSH level of the liver by 35% over control.

3. Prevent lipid peroxidation in hepatocytes
Free radical damage of lipids in a cell membrane is known as lipid peroxidation. This process is prevented by silymarin allowing membrane stability.This mechanism is thought to be primary mode of action in hepatoprotection and keeps amatoxins out of hepatocytes in mushroom poisoning and other form of liver poisoning.

4. Stimulation of hepatic protein synthesis and liver cells regeneration
Silymarin promotes regeneration of liver cells by involving the cell’s DNA. The polymerase A specifically promotes nucleus and heads out into the cytoplasm where it hooks up with the endoplasmic reticulum to do new protein synthesis.

5.Anti-inflammatory effects
Silymarin has been shown to be a potent inhibitor of lipoxygenase enzyme. Silymarin has also shown to inhibit prostaglandin synthesis during inflammation. Silymarin counteracts this deleterious process by suppressing the pathological decomposition of membrane lipids and inhibits prostaglandin formation. As leukotrienes and prostagladins are also involved in the damage of the liver by toxins, their neutralization by silybin is another mechanism for its protection of the liver.

Indication:
Help to maintain normal liver functions

Dosage:
12 years and above –
One tablet two times daily before meal.
The dose can be double in case of severe liver intoxication, and cirrhosis of liver because silymarin is not found to be toxic.

Combination therapy:
MilkThistle should be used in combination with Completec® in cirrhosis of liver and chronic hepatitis for minimum of 6 months.

Side effects:
● Gastrointestinal disturbances because of gall bladder stimulation. These side effects will subside within a week.
● Skin reactions such as pruritus, rash, urticaria and eczema in sensitive individual.
● Headache, arthralgia, rhinoconjunctivitis rarely occur.

Quantity supplied:
60 tablets per bottle

FAME Pharmaceuticals Industry Co., Ltd.
No. 20, Mingyi Mahar Min Gaung Road, Industrial Zone (3), Hlaing Thar Yar City of Industry, 11401, Yangon, Myanmar.
Office: +95 (1) 3685 083, 3682 199, 3685 609, Fax: +95 (1) 3680 122,
E-mail: sale@famepharma.com, drkml@famepharma.com

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