In vitro studies
1. Hypoglycaemic effect: In normoglycaemic rats, oral administration of an aqueous extract of O. aristatus (1g/kg) produces a significant decrease in blood glucose concentration compare with that in a control group.
2. Diuretic effect: In vitro and animal studies in rats have reported diuretic activity of extract of O. aristatus and of flavonoids (sinensetin and tetramethoxyflavone). Oral administration of methylripariochromene A (100 mg/kg) has been shown to increase urinary volume in fasted rats for three hours after oral administration.
3. Anti-hypertensive effect: In stroke-prone, spontaneously hypertensive rats, subcutaneous administration of methylripario-chromene A (100 mg/kg) produced a continuous reduction in systolic blood pressure and a decrease in heart rate. It also suppressed agonist-induced contractions in the rat thoracic aorta and decreased the contractile force in isolated guinea pig atria without significantly affecting the beating (heart) rate.
Clinical studies: A study involving 17 patients with type II Diabetes receiving 8 g of O. aristatus dried leaf in 250 ml boiled water for 30 mins, 3 times per day for 28 days was done in Department of Medical Research (Lower Myanmar). There was a statistically significant reduction of blood sugar level in these patients.
Each tablet contains standard leaf extract of
Orthosiphon aristatus (Java tea) ………… 250 mg
The active principles for controlling blood sugar are diterpenes. There are two groups of diterpenes: isopimarine-type (orthosiphones A and B, orthosiphols A, B, F, G, H and I) and pimarine-type (neoorthosiphols A and B). Other substances include saponins, alkaloids, tannin, essential oil, flavonoids, choline, betaine, organic acids and potassium salts.
For prevention and treatment of type II Diabetes mellitus
For prevention – one tablet daily before dinner
For treatment – one to two tablets two times daily half an hour before meal
Pregnancy and lactating mothers
60 tablets per bottle