|
Home >> Herbal Products >>
Milk Thistle
Milk Thistle
The best liver support
Composition:
Each tablet contains
| |
Milk thistle . . . . . . . . . . . . . . . .
(Standardized to 80% silymarin) |
200 mg |
| |
Soy bean . . . . . . . . . . . . . . . . . |
100 mg |
Indications:
1. Toxic liver damage caused by alcohol,
psychopharmaceuticals and chemicals.
2. Mushroom poisoning
3. Fatty liver
4. Cirrhosis of liver
5. Chronic hepatitis
Side effects:
Numerous studies on silymarin has shown it is virtually
without side effects when used in therapeutic doses. There have been
isolated reports of a mild laxative effect. Toxicity studies show
virtually no damage to any body tissues. It is not cross-react with any
medications, and no contraindications are known.
Bioavailability:
Previously, oral administration of silybin has been limited
by bioavailability. Our product is a conjugate form of silymarin with
phosphotidylcholine from the soy bean and is much more lipophilic (90%
absorption) than silymarin alone.
Dosage:
One tablet two times daily before meal. The dose can be
double in case of severe liver detoxication, and cirrhosis of liver
because silymarin is not found to be toxic.
Preparation:
30 tablets in one bottle.
Pharmacologically active compounds:
The therapeutic efficacy is based on several separate
mechanisms of action.
1. Free radical scavenging activity
Silymarin has a strong affinity for quenching hydroxyl (OH) species,
while having a limited ability to scavenge superoxide (O-2) and peroxide
(H2O2). These are the three most common pro-oxidant species found in
biological systems. This anti-oxidant properly allows silymarin to act
on numerous pathways in the liver and accounts for its many protective
and detoxifying functions.
2. Enhance hepatic glutathione activity
Glutathione is considered one of the most important molecules
for elimination of cytotoxicity in humans. Fortunately, silymarin's
affinity for liver tissue has been shown to substitute for depleted GSH
in hepatocytes, providing free radical scavenging, especially hydroxyl
radicals.
3. Prevent lipid peroxidation in hepatocytes
Free radical damage of lipids in a cell plasmalema causes
leaky membranes, and a myriad of imbalances result from which cells may
or may not recover. Silymarin is noted for its ability to prevent lipid
peroxidation in hepatocytes through its anti-oxidant effect. This is
thought to be silibinin's primary mechanism of action in
hepatoprotection.
4. Promote liver cells regeneration
Silymarin promotes liver regeneration by involving the cell's DNA.
When the cell is told a new protein needs to be made, its starts the
process by creating a more "readable" template of the DNA called a
messenger RNA(mRNA) by the action of enzyme polymerase A. This mRNA
leaves the nucleus and heads out into the cytoplasm where it hooks up
with the endoplasmic reticulum to do new protein synthesis. The
polymerase A specifically promotes the production of mRNA from nuclear
DNA. Silymarin enhances the activity of this polymerase, causing
regeneration in liver cells.
|
